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Nic Wheeler

Nic Wheeler

Postdoctoral Fellow

University of Wisconsin-Madison

Zamanian Lab

Biography

I am a post-doctoral fellow with the Merck KGaA Global Health Institute, performing research in the Yoshino and Zamanian labs at the University of Wisconsin-Madison, where I study vector-borne helminths like Schistosoma mansoni and Brugia malayi, both of which cause neglected tropical diseases. I received my PhD in Genetics and Genomics from Iowa State University, where I was advised by Tim Day.

Interests

  • Parasitology
  • Neglected Tropical Diseases
  • Genomics
  • Sensory Biology
  • Bioinformatics
  • Teaching

Education

  • PhD in Genetics and Genomics, 2017

    Iowa State University

  • BSc in Molecular Biology, 2013

    William Jewell College

Experience

 
 
 
 
 

Research Associate

Zamanian Lab

Jun 2017 – Present University of Wisconsin-Madison
 
 
 
 
 
 
 
 
 
 

Graduate Research Assistant

Iowa State University

Aug 2013 – May 2017
 
 
 
 
 

Undergraduate Researcher

William Jewell College | Indiana School of Medicine | FIOCRUZ (Brazil)

Aug 2009 – May 2013

All Publications

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Genetic and functional diversification of chemosensory pathway receptors in mosquito-borne filarial nematodes

Sensation of a parasite’s environment is absolutely critical to successful transmission and continuation of the parasite’s life cycle. Until now, the molecular receptors that govern these events in parasitic nematodes were largely unknown. We identified chemoreceptive GPCRs and ion channels involved in signal transduction in all of the major parasitic nematodes with available reference genomes. Furthermore, we show for the first time the function of these receptors in chemosensory and thermosensory processess in the filarial nematodes that cause lymphatic filariasis, a major neglected tropical disease that afflicts over 60 million people.

Gene drives for schistosomiasis transmission control

Schistosomiasis is one of the most important and widespread neglected tropical diseases (NTD), with over 200 million people infected in …

Comparative genomics of the major parasitic worms

Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals, decimate …

Sequence and structural variation in the genome of the Biomphalaria glabrata embryonic (Bge) cell line

Background: The aquatic pulmonate snail Biomphalaria glabrata is a significant vector and laboratory host for the parasitic flatworm …

Tissue-specific transcriptome analyses provide new insights into GPCR signalling in adult Schistosoma mansoni

Schistosomes are blood-dwelling trematodes with global impact on human and animal health. Because medical treatment is currently based …

Recent & Upcoming Talks

Contact

  • 1656 Linden Dr., Madison, WI 53706
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